You will join Profs Ali and Buluwela’s laboratory in the Division of Cancer. The team focuses on discovering mechanisms of drug resistance and metastasis in breast cancer and translating these into new therapies. Recent successes include the identification of CDK7 as a new therapeutic target for breast cancer, discovery of an oral CDK7 inhibitor, Samuraciclib, and its progression to clinical trials. We employ functional genomic screens, proteomics, RNA-seq and ChIP-seq for identifying mechanisms of resistance and targetable vulnerabilities. These data are validated in pre-clinical findings from 2D/3D models using gene manipulation genome engineering and selective drugs.
We invite applications for a Bioinformatics Postdoctoral Research Associate to work on the analysis of gene expression (RNA-seq), ChIP-seq, proteomics as well as CRISPR-Cas9 screening datasets that we are generating through our investigations of in vitro and in vivo models of resistance to breast cancer therapies and transcriptomic and epigenomic profiling following treatment of breast and prostate cancer models (in vitro and in vivo) with novel transcription inhibitors, including Samuraciclib.
This position is full time, fixed term for 2 years in the first instance, but comes with the possibility of further funding. You will be based at Hammersmith Campus (East Acton).
Should you require any further details on the role please contact: Prof Simak Ali (simak.ali@imperial.ac.uk)
*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £38,194 to £41,388 per annum*
The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/
The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes which are ultimately aimed towards finding new treatments and making scientific and medical advances, and where there are no satisfactory or reasonably practical alternatives to their use. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. Find out more about animal research at Imperial.
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